Conclusion (2006). The study comprised 758 persons, 490 females and 268 males with recognized OHE in the period October 2001 to November 2002. Human bone marrow-derived mesenchymal stem cells in 2D high density culture and in 3D micromass pellets were treated with chondrogenic induction medium and chondral basal medium in the absence or presence of aqueous extract of burdock root. Aim of the review In the 14th edition of the modern Russian Pharmacopoeia, medicinal plants are described in 107 monographs. Various studies have vaguely proven the fact that several vitamins, minerals, botanicals and secondary metabolites demonstrate hypoglycemic activity in vivo as well as in vitro. Dandelions are revered for their medicinal properties for centuries. Access scientific knowledge from anywhere. In these studies, an increase in somatotropin was documented with no increase in mucus production. The inhibitory compound was isolated from the ethyl acetate extract and identified as sitosterol-β -D-glucopyranoside (1) by EI-MS, FAB-MS, IR, 1H and 13C NMR spectroscopy. Only in tape-stripped skin did TEWL stay at high levels during treatment with self-adhesive dressings. Repair of water barrier function was evaluated by daily measurements of transepidermal water loss (TEWL) for 1 week. Herbal medicine in Russia has a long history starting with handwritten herbalist manuscripts from the Middle Ages to the officinal Pharmacopoeia of the 21st century. wild burdock. The fruit constituents, the fruit pulp (pomace), which contains 11% proteins, 19% lipids, and 34% inulin, have been reported on as well.Chan 2011, Jeelani 2012, Li 2013, Wang 1993, Yamaguchi 1976 Methods of extraction and identification have been published.Jaiswal 2011, Lou 2012, In vitro and animal studies have attempted to elucidate a mechanism of action for the anti-inflammatory effect of burdock. Bath teas are developed from medicinal herbal baths and are composed of raw herbs and only raw herbs. wild rhubarb. For instance, cinnamon could be a more favorable choice for diabetic hypertensive patients. Status Milk thistle has become particularly problematic in California where it has been listed as an invasive species of weed. Individual case reports suggest that the tea improves quality of life, alleviates pain, and in some cases, impacts cancer progression among cancer patients. Currently, no clinical studies of Essiac™ or Flor‐essence™ are published, but a clinical study is being planned at the British Columbia Cancer Agency by the University of Texas‐Center for Alternative Medicine (UT‐CAM) and Tzu‐Chi Institute for Complementary and Alternative Medicine. Proposed mechanisms of action include an inhibitory effect on alpha-glucosidase by sitosterol and an effect by inulin on plasma glucose levels.Chan 2011 Other experiments have evaluated total lignans (eg, lappaol, arctigenin, arctiin, arctignan) and individual lignans for effect, finding stimulation of insulin secretion, enhanced regeneration of islet cells, and inhibition of gluconeogenesis.Huang 2012, Miele 2012, Xu 2014 An older experiment, however, found a lack of effect of burdock in a streptozotocin-induced diabetic mouse model.Swanston-Flatt 1989 In addition, in rats with induced diabetic nephropathy, arctiin reduced albinuria and glomerular filtration damage, as evaluated by histology.Ma 2013 Following a study examining arctigenin's effect on increased physical endurance and time to fatigue in mice, a role in diabetes was postulated,Tang 2011 while positive effects on cholesterol efflux suggest the chemical may contribute to managing associated hyperlipidemia.Xu 2013. The aim of the study was to elucidate whether aqueous extract of burdock root regulates mesenchymal stem cell proliferation and differentiation. © 2008-2020 ResearchGate GmbH. Moreover, Aloe vera leaf gel extract demonstrates significant activity in diabetes. Male erectile dysfunction (ED) refers to incompetency to reaching and retaining adequate penile tumescence for sexual intercourse. major extracts and related compounds in vitro, dibenzylbutyrolactone lignan, inhibits MAP kinases and AP, dibenzylbutyrolactone lignans through inhibition of I. phosphorylation and of p65 nuclear translocation in macrophages, inhibitors of human immunodeficiency virus type, PI3K/Akt pathway and induced apoptosis in human leukemia HL, mammary, colon and pancreatic carcinogenesi. (2008). The most frequently recognized diagnosis was irritant contact dermatitis (ICD), mainly caused by wet occupations. A thistle-like plant whose prickly heads have a hook-and-loop system they use to latch onto passers-by, burdock root has been used for food and to promote good health by cultures around the world. A. lappa reversed the decrease in GSH and P-450 induced by CCl4 and acetaminophen. The species is also consumed as a vegetable in the form of salad and stew because of its high nutritional composition. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Scientific Name(s): Arctium lappa L.Common Name(s): Fructus arctii, Bardana, Beggar's buttons, Clotbur, Edible burdock, Goboushi (Japanese), Great bur, Great burdocks, Lappa, Niu Bang Zi (Chinese). It has also been promoted as an aphrodisiac and used topically for various skin problems. In an attempt to elucidate the possible mechanism(s) of this hepatoprotective effect, glutathione (GSH), cytochrome P-450 (P-450) and malondialdehyde (MDA) contents were studied. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. Diabetes, CNS conditions, gastric ulcer, and colitis are under investigation for possible therapeutic use; however, not enough clinical evidence is available to recommend burdock for any condition. Test results were significant (p<0.05) in growth parameters in response to phosphorous and the number of leaves in potassium treatments. MEB directly scavenged nitric oxide in a concentration-dependent fashion (p < 0.05). The majority of the studies done for the detection of the efficacy of medicinal plants in treating male infertility were done on experimental animals with few clinical studies. Burdock root is sometimes used as food. Dosages reported include 6 g/day of burdock root tea.Maghsoumi-Norouzabad 2016 A 28-day phase I dose-determination trial conducted in patients with advanced refractory pancreatic cancer recommended 12 g/day.Ikeda 2016, Avoid use. The first patient was 11 months old with 17% total body surface area (TBSA) partial and full-thickness scald burns to her lower extremities. No harmful effects were seen.Maghsoumi-Norouzabad 2016, Burdock has been used as a natural aphrodisiac. Compound 1 inhibited 97.3% of α-glucosidase activity at a concentration of 200.0 μ mol/mL, and the ID50 (50% inhibition dose) value was 30 μ mol/mL. We comply with the HONcode standard for trustworthy health information -. Results: Unlike most online dictionaries, we want you to find your word's meaning quickly. Identification of arctigenin as an, S. H., Azmi, A. S., and Hadi, S. M. (2007). NK cell activity, the primary outcome, significantly increased in CAEC when compared with the placebo at effector-to-target (E:T) ratios of 25:1 and 50:1 after 8 weeks. You should talk with your health care provider for complete information about the risks and benefits of using this product. Since, (Niggemann and Gruber, 2003). Allergic dermatitis and anaphylaxis have been reported. This knowledge could be used in the future in drug discovery for the development of more natural drugs with no side effects. Although burdock is also consumed for medicinal purposes, it is more commonly consumed as food, such as in Japan where burdock is cultivated for sale in markets. Whole root extract restored canine dermal fibroblast integrity following peroxide damage in 1 experiment,Pomari 2013 and a protocol was published for a clinical trial in Korea that used topical ethanol seed extract to treat dry skin.Lee 2013 An uncontrolled observational interventional study was undertaken to determine the effectiveness of a homeopathic preparation of Lappa (Arctium lappa) in the treatment of acne vulgaris in young adults. Burdock is a versatile plant frequently classified by herbalists as an alterative, a plant, … In addition, the procedure is not without possible risks. No dose-limiting toxicity was observed at any of the 3 doses tested (3, 7.5, and 12 g/day) and adverse events were extremely mild. There have been a lot of, the rapid proliferation of the tumor cells, oxidants and some other active polyphenol antioxidants found in the root of, , 1993). The survey was conducted between 2008 and 2018, in the databases Science Direct, Lilacs, PubMed, and Web of Science (main collection), as well as the SciELO Citation Index. The goal of this review was to inscribe various classes of secondary metabolites in particular those obtained from plants, and their role in the treatment of DM. Methods The estimated rates of OHE were high for bakers, hairdressers and dental surgery assistants, and a high proportion of apprentices were found among hairdressers. Both patients ultimately underwent surgical interventions. The average treatment duration was 8.2 days, whereas the mean healing time was 13.8 days (range, 5 to 23 days) with only 1 of the 5 participants using analgesics. In addition, at a concentration of 500 μg/ml, the inhibitory effect of MEB on LDL oxidation was 66.9% compared to the control (p < 0.05). Recent advancements for recognizing the markers which can be employed for identifying altered metabolic pathways, biomarker discovery, limitations, metabolic markers of drug potency and off-label effects are also reviewed. Results It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. However, there is still a need for more studies to have certain results, as conflicting results were noted in different studies done on the effect of the same medicinal plant on spermatogenesis. Reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed that the expression of iNOS and COX-2 mRNA in activated macrophages were suppressed by a high concentration (500 μg/ml) of MEB. Background It is used to treat conditions cause by and ‘overload’ of toxins, such as throat and other infections, boils, rashes, and other skin problems. The proportion of occupational ICD was equal for males and females, 59.7% and 63.1%, respectively. Last updated on Jan 20, 2020. Burdock root has been consumed as food in Asia for many centuries. The experimental study of the effect of anti-decrepitude of Arctium lapepa L. The effect of the ingestion of burdock root on normal and diabetic individuals: A preliminary report. Select one or more newsletters to continue. In this review, we highlight the therapeutical potential of new plants included in the modern edition of the Russian Pharmacopoeia. Burdock is on of the foremost detoxifying herbs in both Chinese and Western herbal medicine. Burdock Root which is known by many names such as Hardock, Hareburr, Turkey Burrseed, Great Burr, Cocklebur, Beggars Buttons, Cockle Buttons, Lappa, Bardane, Thorny Burr, Fox’s Clote, Love Leaves, Personata, Clotbur, Happy Major is well known for its cosmetic uses and lesser known as a medicinal herb nowdays – It was not always so….. The protective effects of burdock (Arctium lappa Linne) on oxidation of low-density lipoprotein (LDL) and nitric oxide production were investigated. Available for Android and iOS devices. A., and Krantz Jr, J. C. (1931). An herbal burn and wound ointment was applied to the wound, which was then wrapped in a layer of burdock leaves. This species can spread rapidly through the dispersal of its hooked fruits, which attach themselves to clothing and animal fur. to provide a comprehensive overview of this herb. Digestive Support, Immune Support, Liver & Cleanse Support, Beauty & Radiance Support. However, it is also essential to be aware of the side effects of burdock including contact dermatitis and other allergic/inflammatory responses that might be evoked by burdock. This herb is mainly used for digestive and liver problems but also has some other health benefits, such as a skin cleanser to treat acne, treatment of urinary tract infections, to boost energy and stamina, treat ulcers, cleanse the colon and treat psoriasis and eczema. The sesquiterpene had a good activity against Acanthamoeba castellanii Neff and a low cytotoxicity effect in murine macrophages cells lines. Results The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Almost a century later the technique, despite its empirical basis, has with refining and, Occupational hand eczema (OHE) is the most frequently recognized work-related disease in Denmark and the annual cost to society is high. This current review will emphasise the aetiology, risk factors, mechanisms underlying the pathophysiology of ED, treatments of ED as well as their side effects. It did not have significant effect on osteogenic and adipogenic differentiation, but significantly enhanced chondrogenic induction medium-induced chondrogenesis. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. This is only a brief summary of general information about this product. The methanolic extract from the seeds of Arctium lappa was found to inhibit the LPS-induced nitric oxide (NO) production in murine macrophage RAW264.7 cells. In traditional medicine, burdock fruits, seeds, roots, and leaves have been used as decoctions or teas for a wide variety of ailments, including colds, catarrh, gout, rheumatism, stomach ailments, and cancer, as well as use as a diuretic, diaphoretic, and laxative. In the presence of supplemental materials, burdock root aqueous extract showed equivalent chondrogenic induction capability to that of TGF-β. Additionally, significant improvements were seen with burdock root tea compared to controls in glutathione (P=0.003), malondialdehyde (P=0.021), and total antioxidant capacity (P=0.004). The primary aim of this case series is to highlight the use and clinical outcomes of this treatment for paediatric Amish patients. and MeIQx-induced hepatocarcinogenesis in male F344 rats. Managing burn wounds with B&W ointment and burdock leaves should be considered as an additional option for wound care in select cases. Use an herbicide to control the burdock plant's rosettes in their first year of growth. bacteria related to endodontic pathogens such as: Chlorogenic acid isolated from the leaves also. Hence, we anticipate that CAEC can be developed as a functional food for stimulating immunity. Sexual function greatly affects the quality of life. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. Lesser burdock, also called common burdock, was introduced from Europe in the 17th century for its medicinal and culinary purposes. Recent evidence has found that burdock root can remove toxins from the bloodstream. Burdock root is commonly used as food in Asia. This information relates to an herbal, vitamin, mineral or other dietary supplement. A … Burdock is generally considered a safe and edible food product, but toxicology studies are lacking. Some of the included plants are not endemic to Russia and do not have a history of traditional use, or on the other hand, are widely used in Western medicine. In the seeds, some active compounds possess anti-inflammatory effects and potent inhibitory effects on the growth of tumors such as pancreatic carcinoma. The patent survey was carried out on the basis of the Derwent Innovations Index, an important source for worldwide patent consultation, which covers 20 y of registered patents. A. lappa suppressed the SGOT and SGPT elevations induced by CCl4 or acetaminophen in a dose-dependent manner and alleviated the severity of liver damage based on histopathological observations. The taste resembles that of artichoke, a burdock relative. In rodents, arctigenin and the lactone onopordopicrin have been shown to reduce the extent of induced colitis.de Almeida 2013, Hyam 2013 Onopordopicrin extracted from A. lappa leaves has also been evaluated for its antisecretory effect on gastrin in gastric ulcers and induced lesions in rat studies. After 90 min of incubation, Belcils® induced, DNA condensation, collapse in the mitochondrial membrane potential and reduction of the ATP level production in Acanthamoeba. False-positive and false-negative reactions can occur [2–4]. Side, Pari, L., and Prasath, A. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The leaves contain triterpenoids, while the root contains vitamins A, B1, B2, and C, as well as minerals including calcium, iron, potassium, magnesium, manganese, sodium, zinc, and copper. Arctium lappa L. root (burdock root) has long been recommended for the treatment of different diseases in traditional Chinese medicine. Therefore, public awareness about the possibility of, and State Key Laboratory of Chinese Medicine and Molecular, by caffeic acid in human peripheral lymphocytes: Involvement of endogenous. The second patient was 24 months old with 20% TBSA partial-thickness scald burns to the torso, bilateral upper extremities, neck and chin. Some species have a traditional use and are present even in the Phytotherapic Summary of the Brazilian Pharmacopeia. Herbicides recommended in the treatment of first-year burdock include 2,4-D, MCPA, 2,4-DB, and dicamba. We have therefore evaluated the effect of various occlusive treatments on repair of the human skin permeability barrier under controlled experimental conditions. Reason to love: Who wouldn't love the herb that inspired the invention of velcro. The information was collected from local libraries in Saint-Petersburg, the online databases E-library.ru, Scopus, Web of Science, and the search engine Google scholar. Copyright © 2000 John Wiley & Sons, Ltd. In Europe, burdock root oil, also known as bur oil, is commonly used as a scalp treatment to help prevent hair loss and get rid of dandruff. Yet, for a long time, Russian traditional and officinal herbal medicine was not well known to the international audience. are no controlled clinical studies of the effect of occlusion on irritated human skin. The prevalence of occupational allergic contact dermatitis in the study population was substantially higher among males than females, and the most frequent causes among males were allergy to chromium (leather exposure), rubber additives (gloves) and nickel due to exposure from work tools and metalworking industry. Padre Tomas, State Key Laboratory of Chinese Medicine and Molecular P, effects of the active compounds present in, have been reported. Burdock is one of the key ingredients of Essiac and Flor-Essence, herbal formulas marketed as wonder remedies for people coping with cancer. The protective effect might be due to OLE competence to antagonize the oxidative stress and LPO. In the leaf extract, the active compounds isolated can inhibit the growth of micro-organisms in the oral cavity. New medicinal plants included in the 14th edition of the Russian Federation’s State Pharmacopoeia were selected. Dosages reported include 6 g/day of burdock root tea, and 12 g/day of a burdock fruit extract for advanced refractory pancreatic cancer. The response rate and disease control rate were deemed to be 6.7% and 33.3%, respectively, whereas the median progression-free and overall survival times were 1.1 months and 5.7 months, respectively.Ikeda 2016, In a rodent model of brain injury due to ischemia, arctigenin suppressed microglial activation; reduced interleukin and tumor necrosis factor expression, resulting in a lower neural deficit score; and decreased infarct volume when compared with no intervention.Fan 2012 Inhibition of beta-amyloid production, decreased senile plaques, and decreased memory impairment was shown in mice administered arctigenin. i.p.). The blockade of Cys, inflammatory response. Experimental studies with individual herbs have shown evidence of biological activity including antioxidant, antioestrogenic, immunostimulant, antitumour, and antiocholeretic actions. The root, leaf, and seed are used to make medicine. MEB, at 200 μg/ml, not only enhanced GSH levels, but also increased activity of GSH reductase, GSH peroxidase, GSH transferase and catalase, which were 3.82-, 24.9-, 4.35- and 3.02-fold compared to the control (p < 0.05), respectively. This product may be unsafe when used before surgery or other medical procedures. In our previous comprehensive review, we discussed the pharmacological effects of specific plants included in the 11th edition of the Pharmacopoeia of the USSR, which was also for a while used in Russia. Lesser Burdock produces purple flowers in its second year of growth, from July to October. The dried root of one year old plants is the official herb, … A curious herbal: containing five hundred cuts, of the most useful plants, which are now used in the practice of physick. Compositae is the largest family of flowering plants, with more than 1600 genera and 22 000 species. Try the world's fastest, smartest dictionary: Start typing a word and you'll see the definition. Burdock has been used therapeutically in Europe, North America and Asia for hundreds of years. The 14th edition of the Russian Federation’s State Pharmacopoeia was implemented in 2018. Common burdock (Arctium minus) is a tall, invasive biennial herb known for clinging burs that were not only the inspiration for Velcro, but also for lowering the health and market value of livestock.The burs get tangled in manes and tails of horses, cows and other livestock, and can also damage or de-value the wool of sheep. Lps ) -induced raw 264.7 cells the 14th edition of the Russian Pharmacopoeia xyloglucan has been used as an S.., partly alter pre-treatment with petrolatum weeks after transplant traditional Chinese medicine ( TCM ), mainly caused by occupations... Acids is also consumed as a flavouring in the future in drug discovery for the latest medication news, drug!, an increase in somatotropin was documented with no side effects you receive from your health provider. 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That occlusive treatment of male ED the main active components of the most common traditional uses for root! Species have a traditional use, pharmacological, clinical application, and Prasath, a recognized in..., hawthorn berry reproducing allergic eczema, following application of sodium lauryl sulfate SLS...