In relation to fatigue, which is a physiological phenomenon, asthenia by its chronic, irrational and little reversible aspect has to do with the epidemiological pathology – importance of the problem “. In the past, the terms “asthenia” and “weakness” were used to describe a subjective sensation of tiredness, while the specific term “fatigue” was used to describe a symptom of tiredness precipitated … Copyright © In an audit of one neurologic practice, anxiety and depressive reactions were the main diagnosis in 20 percent of patients, second only to the symptom of headache (Digon et al). Asthenia is the weakness and fatigue that result from physical and mental stress. In this chapter, we consider the clinically related phenomena of lassitude, fatigue, nervousness, irritability, anxiety, and depression. Fatigue can cause other symptoms such as memory loss, sweating and general feeling of discomfort. Although more abstruse than paralysis, sensory loss, seizures, or aphasia, they are no less important, if for no other reason than their frequency. How to use asthenia in a sentence. A person experiencing weakness may not be able to move a certain part of their body properly. Asthenia vs. myasthenia Asthenia and myasthenia are different conditions that involve weakness in one or more parts of the body.